Antiinflammatory action of glucocorticoids--new mechanisms for old drugs.

By T. Rhen, J. Cidlowski. New England Journal of Medicine, 2005

2,988 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics

View Paper: https://www.semanticscholar.org/paper/d138afb089729bf3c4461d201b43612e07587c4b

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In Endocrinology, Diabetes and Metabolism

In Genetics

Citations in the corpus

Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19 (2020, neutral): “5 (22-78) 63 (38-74) 65 (46-73) Age subgroups (y) 0-15 0 of 50 (0%) 0 of 14 (0%) 0 of 25 (0%) 0 of 11 (0%) 16-59 18 of 50 (36%) 9 of 14 (64.”
Social regulation of gene expression in human leukocytes (2007, background): “Cortisol activation of the glucocorticoid receptor (GR) exerts broad anti-inflammatory effects by inhibiting nuclear factor (NF)-κB/Rel transcription factors and other pro-inflammatory signaling pathways (for example, the Janus kinase-signal transducer and activator of transcription (JAK/STAT) and i”
Interactions between Temperament, Stress, and Immune Function in Cattle (2011, background): “Approximately 1–10% of cortisol circulates as a “free” steroid [31, 32].”
Reciprocal regulation of the neural and innate immune systems (2011, background): “This effect is mediated by three mechanisms, namely: suppressive binding of the glucocorticoid receptor to gene promoter sequences; glucocorticoid receptor-mediated transcriptional induction of anti-inflammatory genes (such as NFKBIA , which encodes IκBα); and non-genomic antagonism of pro-inflamma”
Annexin A1 and glucocorticoids as effectors of the resolution of inflammation (2009, background): “During inflammation, increased levels of cortisol dampen local and systemic inflammatory events, thereby favouring proper resolution of the inflammatory respons”
Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017, background): “In contrast, increased norepinephrine production following stressor exposure induces NFκB activity that activates the immune system and increases cytokine production (Bierhaus et al, 2003).”
Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome (2019, background): “Commonly recommended standard therapies for IBD-UC patients are corticosteroids [17], amino-salicylates [18,19], and immunosuppressive agents [20,21].”
From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression (2014, background): “It is therefore a prototype for some of the most effective anti-inflammatory drugs (Pace, Hu, & Miller, 2007; Rhen & Cidlowski, 2005).”
American Society of Hematology 2019 guidelines for immune thrombocytopenia. (2019, neutral): “Side effects taken into consideration included hypertension, hyperglycemia, sleep and mood disturbances, gastric irritation or ulcer formation, glaucoma, myopathy, and osteoporosis.(45,58-60)”