Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information…

By H. Sofia, Guang Chen, Beth Hetzler, Jorge F. Reyes-Spindola, N. Miller. Nucleic Acids Research, 2001

948 citations recorded by the source corpus.

Subfields: Cell Biology, Organic Chemistry, Renewable Energy, Sustainability and the Environment

View Paper: https://www.semanticscholar.org/paper/d12c0b801ce7e1e5d5b22e22b9537e0e6bd94f82

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Citations in the corpus

Phylogeny of the bacterial superfamily of Crp-Fnr transcription regulators: exploiting the metabolic spectrum by controlling alternative gene programs. (2003, methodology): “Conserved associations between Crp-Fnr members and nearby genes, such as are often found, for example between operons encoding the same pathway in various species, were analyzed with an approach based on Similarity Box analysis [15] using Perl, Java, and UNIX tools.”
Bacillus: A Biological Tool for Crop Improvement through Bio-Molecular Changes in Adverse Environments (2017, background): “…al., 2011; Wang et al., 2012; Kasim et al., 2013; Lim and Kim, 2013; Timmusk et al., 2015) and lower gene expression levels of APX1 (ascorbate peroxidase 1), SAMS1 (S-adenosylmethionine synthetase 1, which acts as methyl donor and a precursor to polyamines synthesis (Sofia et al., 2001) andHSP17.”
The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics (2006, background): “Comparison with other protein sequences deposited in the databases showed that the Cfr protein is not related to other known resistance-conferring rRNA methyltransferases but rather to the Radical SAM superfamily (9), which includes a wide range of enzymes from a diverse set of bacteria involved in ”
TIGRFAMs and Genome Properties in 2013 (2012, background): “…sequences in public protein sequence databases are annotated incorrectly as biotin synthase (EC 2.8.1.6), to give one example, through errors of transitive annotation, in part because biotin synthase was one of the ﬁrst radical SAM superfamily (14) members sequenced, characterized and named (15).”
The Radical SAM Superfamily (2008, methodology): “A search of the protein sequence database for this motif, together with a SAM binding motif, netted more than 580 proteins in 2001, and this group was named the radical SAM superfamily (Sofia et al., 2001).”