The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics

By K. Long, J. Poehlsgaard, C. Kehrenberg, S. Schwarz, B. Vester. Antimicrobial Agents and Chemotherapy, 2006

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The RNA modification database, RNAMDB: 2011 update (2010, background): “Whereas the m 2 A chemistry shows only a small amount of antibiotic resistance (28), the m 8 A moiety confers extensive resistance to ﬁve major classes of peptidyl transferase-targeting anti-biotics (29).”
Antibiotic resistance in Staphylococcus aureus. Current status and future prospects (2017, background): “Cfr stands for chloramphenicol and florfenicol resistance, the phenotypes with which the determinant was associated when first detected (Long et al. 2006).”
Intrinsic and acquired resistance mechanisms in enterococcus (2012, background): “It is hypothesized that the cfr gene emerged from animal strains of bacteria that were exposed to natural compounds with an rRNA binding site similar to linezolid.(101,102) In 2011, cfr was identified in an E.”
A Field Guide to Pandemic, Epidemic and Sporadic Clones of Methicillin-Resistant Staphylococcus aureus (2011, background): “, vanA-mediated vancomycin resistance [18] and cfr-mediated linezolid resistance [19–21].”