Identification of Regulatory T Cells in Tolerated Allografts
By L. Graça, S. Cobbold, H. Waldmann. Journal of Experimental Medicine, 2002
600 citations recorded by the source corpus.
Induction of transplantation tolerance with certain therapeutic nondepleting monoclonal antibodies can lead to a robust state of peripheral “dominant” tolerance. Regulatory CD4+ T cells, which mediate this form of “dominant” tolerance, can be isolated from spleens of tolerant animals. To determine whether there were any extra-lymphoid sites that might harbor regulatory T cells we sought their presence in tolerated skin allografts and in normal skin. When tolerated skin grafts are retransplanted onto T cell–depleted hosts, graft-infiltrating T cells exit the graft and recolonize the new host. These colonizing T cells can be shown to contain members with regulatory function, as they can prevent nontolerant lymphocytes from rejecting fresh skin allografts, without hindrance of rejection of third party skin. Our results suggest that T cell suppression of graft rejection is an active process that operates beyond secondary lymphoid tissue, and involves the persistent presence of regulatory T cells at the site of the tolerated transplant.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/d0bef7def7ec46dfa61bb55d810689a621871d2c
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In Immunology
Citations in the corpus
- Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells1 (2003, result): “Similar results have been described in a model of transplantation tolerance (15).”
- Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. (2004, background): “Recently it has been demonstrated that regulatory T (Treg) cells have a role in the induction of transplantation tolerance (Graca et al., 2002; Karim et al., 2002; Bach, 2003; Bluestone and Abbans, 2003; Word and Sakaguchi, 2003).”
- Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells (2004, background): “It is tempting to speculate that those T cells with suppressive potential that could be isolated from effector sites such as synovial fluid of rheumatoid arthritis patients (45), lung tumors (46), transplants (47), skin lesions of Leishmania major–infected mice (17), islets of Langerhans in a diabet”