Human aneuploidy: mechanisms and new insights into an age-old problem
By So I. Nagaoka, T. Hassold, P. Hunt. Nature reviews genetics, 2012
953 citations recorded by the source corpus.
Trisomic and monosomic (aneuploid) embryos account for at least 10% of human pregnancies and, for women nearing the end of their reproductive lifespan, the incidence may exceed 50%. The errors that lead to aneuploidy almost always occur in the oocyte but, despite intensive investigation, the underlying molecular basis has remained elusive. Recent studies of humans and model organisms have shed new light on the complexity of meiotic defects, providing evidence that the age-related increase in errors in the human female is not attributable to a single factor but to an interplay between unique features of oogenesis and a host of endogenous and exogenous factors.
Subfields: Genetics, Pediatrics, Perinatology and Child Health, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/d0b46ef7c7de617ddec83be6c96f00ff1f2ce236
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In Genetics
In Pediatrics, Perinatology and Child Health
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Citations in the corpus
- Meiotic Recombination: The Essence of Heredity. (2015, background): “Although aging clearly impacts oocyte chromosome segregation via multiple pathways (Hassold and Hunt 2001; Selesniemi et al. 2011; Nagaoka et al. 2012), a number of studies indicate that progressive weakening of sister-chromatid cohesion is likely to be a major mechanism (Wolstenholme and Angell…”
- Design and Analysis of Single-Cell Sequencing Experiments. (2015, background): “Moreover, a surprisingly high frequency of chromosomal abnormalities has been observed during mammalian germline development (Nagaoka et al., 2012).”
- A visual analytics approach to understanding cycling behaviour (2012, neutral): “These cases have similar We numbers (254 compared to 264), but different density ratios (695 compared to 79).”
- Diagnosis of human preimplantation embryo viability. (2015, background): “Trisomic and monosomic embryos account for at least 10% of human pregnancies and, for women nearing the end of their reproductive lifespan the incidence can exceed 50% (Nagaoka et al., 2012).”