Therapeutic Nanoparticles for Drug Delivery in Cancer

By Kwangjae Cho, Xu Wang, Shuming Nie, Zhuo Georgia Chen, D. Shin. Clinical Cancer Research, 2008

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PLGA-based nanoparticles: an overview of biomedical applications. (2012, background): “Initial lymph vessels have diameters around 10–60 μm whereas the sinusoids in the spleen vary from 150 to 200 nm [60].”
Optimized metal-organic-framework nanospheres for drug delivery: evaluation of small-molecule encapsulation. (2014, background): “bility, nonspecific targeting, and low cellmembrane permeability.(1) In many cases,”
Silver nanoparticles: Synthesis, medical applications and biosafety (2020, background): “Due to the enhanced permeability and retention (EPR) effect, tumor cells preferentially absorb NPs-sized bodies than normal tissues [33, 34].”
Metal-Organic Frameworks as Potential Drug Carriers (2010, neutral): “Typically, a nanoparticle therapeutic is composed of an active agent incorporated within the nanoparticle carrier; a variety of nanocarriers have been used for this purpose, such as polymeric nanoparticles, micelles, liposomes, iron oxide, and gold [3,4].”
Design of Curcumin Loaded PLGA Nanoparticles Formulation with Enhanced Cellular Uptake, and Increased Bioactivity in vitro and Superior Bioavailability in vivo (2009, neutral): “Another way to solve the problem of lack of water solubility and poor oral bioavailability, is polymer-based nanoparticles [27].”