Metal-Organic Frameworks as Potential Drug Carriers

By Rachel C Huxford, J. D. Rocca, Wenbin Lin. Current Opinion in Chemical Biology, 2010

784 citations recorded by the source corpus.

Summary of Recent Advances Nanoparticle-based therapeutics have received increasing attention, as these systems can alleviate many drawbacks of conventional therapy. Metal-organic frameworks (MOFs), a new class of hybrid materials composed of metal ions and organic bridging ligands, have emerged as a promising platform for drug delivery, owing to their high drug loadings, biodegradability, and versatile functionality. The bulk MOF materials can absorb and release large amounts of therapeutics including ibuprofen, procainamide, and nitric oxide. Scale-down of MOFs to the nano-regime yields nanoscale metal-organic frameworks (NMOFs) which are more applicable as delivery vehicles, such as selective delivery of cisplatin prodrugs. Although progress has been made in utilizing NMOFs for drug delivery, many improvements must occur before they can become viable nanotherapeutics.

Subfields: Biomaterials, Inorganic Chemistry, Polymers and Plastics

View Paper: https://www.semanticscholar.org/paper/66a78154450e224d8967d332e0d4e89cad6f63cc

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Citations in the corpus

• High drug-loading nanomedicines: progress, current status, and prospects (2017, positive): “MOFs consist of transition metal ions/clusters and multidentate organic ligands, and are typically synthesized via coordinationdirected self-assembly processes under mild conditions (Figure 4).(97) Over the past two decades, MOFs have been applied in photonics,(98) catalysis, biosensors,(102,103) ga”