Nonnatural protein–protein interaction-pair design by key residues grafting

By Sen Liu, Shiyong Liu, Xiaolei Zhu, Huanhuan Liang, Aoneng Cao, Z. Chang, Luhua Lai. 2007

86 citations recorded by the source corpus.

Subfields: Biotechnology, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. I. Samish

In Molecular Biology

1. I. Samish
2. P. Benjamin Stranges
3. M. Miley
4. A. Tripathy
5. Brian Kuhlman
6. M. Machius
7. David Baker
8. Tanja Kortemme

Citations in the corpus

• Achievements and Challenges in Computational Protein Design. (2017, methodology): “In 2007 Lai and coworkers de novo designed a protein that binds the erythropoietin receptor [63].”
• Computational design of a symmetric homodimer using β-strand assembly (2011, background): “Other methodologies have focused on grafting side-chain interactions from a known interaction onto another scaffold (7, 11, 12).”
• Computational design of a protein-based enzyme inhibitor. (2013, unknown): “By grafting three hot spot residues from erythropoietin onto the surface of an unrelated protein of correct shape, a new binder to the erythropoietin receptor with modest affinity was designed [10].”