Losartan-Dependent Regression of Myocardial Fibrosis Is Associated With Reduction of Left Ventricular Chamber Stiffness in Hypertensive Patients

By J. Dı́ez, R. Querejeta, B. López, Arantxa González, M. Larman, J. L. Martínez Ubago. Circulation, 2002

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Pathological Ventricular Remodeling: Mechanisms: Part 1 of 2 (2013, background): “Interestingly, the expression of angiotensin II receptors in cardiac fibroblasts exceeds that in cardiac myocytes,(103) and angiotensin receptor blockers appear to have antifibrotic actions.(104) In patients with hypertensive heart disease, losartan reduced cardiac fibrosis and serum collagen marker”
Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease (2012, background): “Excess collagen deposition and fibrosis has been clearly linked to myocardial stiffness, diastolic and systolic dysfunction [95].”
Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement (2013, neutral): “mechanical [25-27], electrical [28-31], and vasomotor”
Assessment of Myocardial Fibrosis with Cardiac Magnetic Resonance (2011, background): “It is reversible under specific therapy (4,33,34).”