Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages

By J. Timmons, K. Wennmalm, O. Larsson, Tomas B. Waldén, Timo Lassmann, N. Petrovic, D. Hamilton, Ruth E. Gimeno, Claes Wahlestedt, K. Baar and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2007

752 citations recorded by the source corpus.

Subfields: Biochemistry, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/d052f37db23a71995536a9da31b7cfb400f70644

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. B. Spiegelman
2. H. Ohno
3. Jun Wu
4. E. Rosen
5. Kosaku Shinoda
6. Toren Finkel
7. S. Kajimura
8. N. Tonks

In Epidemiology

1. B. Spiegelman
2. S. Kajimura
3. E. Rosen
4. H. Ohno
5. Jun Wu
6. Kosaku Shinoda
7. Toren Finkel
8. G. Hotamışlıgil

In Physiology

1. S. Kajimura
2. B. Spiegelman
3. E. Rosen
4. Jun Wu
5. P. Cohen
6. Toren Finkel
7. H. Ohno
8. Kosaku Shinoda

Citations in the corpus

• Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. (2015, neutral): “As an independent line of evidence, the transcriptional profile of classical brown adipocytes resembles that of skeletal muscle cells (34, 35).”
• Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “Gene expression profiling experiments had previously shown that classical brown fat cells from the interscapular region expressed certain genes typically found in skeletal muscle cells (Timmons et al. 2007).”
• PPAR agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein (2012, neutral): “Furthermore, global gene expression analyses indicate that classical interscapular brown fat precursors have a gene profile overlapping that of skeletal muscle cells (Timmons et al., 2007).”
• Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells (2012, background): “precursors in the interscapular BAT show a gene signature that resembles that of skeletal muscle cells [14].”
• Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling (2011, background): “Immature undifferentiated brown fat cells harbor muscle-specific transcripts and microarray analyses revealed that brown preadipocytes exhibit a myogenic transcriptional signature (Timmons et al., 2007).”
• Developmental origin of fat: tracking obesity to its source. (2007, neutral): “Indeed, brown preadipocytes have been reported to possess a “myogenic” signature, providing additional evidence for distinct origins of BAT and WAT and a potential link to the energy-burning function of BAT (Timmons et al., 2007).”
• Ontology-Based Meta-Analysis of Global Collections of High-Throughput Public Data (2010, methodology): “To identify genetic perturbations that resulted in altered gene expression patterns similar to the brown preadipocyte signature, we again used the 2,302 probe set derived by comparing the gene expression profiles of brown and white preadipocytes (Table S4) [23].”
• What We Talk About When We Talk About Fat (2014, positive): “Inducible brown precursor cells can be isolated from muscle, and muscle and brown fat share overlapping gene expression patterns (Schulz et al., 2011; Timmons et al., 2007).”