CD45: a critical regulator of signaling thresholds in immune cells.

By M. Hermiston, Zheng Xu, A. Weiss. Annual Review of Immunology, 2003

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Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. (2009, background): “…shown by separating FoxP3+ cells into three subsets based on the expression of FoxP3 and CD45RA (or CD45RO), which Immunity 30, 899–911, June 19, 2009 ª2009 Elsevier Inc. 905 controls signaling thresholds in lymphocytes, hence their state of differentiation and activation (Hermiston et al., 2003).”
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation (2004, background): “CD45 specifically dephosphorylates the C-terminal Y505 residue of Lck and is thought to be a critical positive regulator of Lck and Fyn in T cells (Hermiston et al., 2003).”
Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses (2005, background): “Second, we have omitted explicit specification of a number of molecules that are well documented in the literature to affect T-cell signaling responses, such as CD45, Csk, and several adapter proteins [63,64].”