Phenotypic Diversity, Population Growth, and Information in Fluctuating Environments

By Edo Kussell, Stanislas Leibler. Science, 2005

1,374 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Sociology and Political Science

View Paper: https://www.semanticscholar.org/paper/d01dea0633607266916f9a3f25d55f8fe2fff140

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Alexander van Oudenaarden
2. Arjun Raj
3. Johan Paulsson
4. Peter S. Swain
5. Paul C. Bressloff
6. James J. Collins
7. Michael B. Elowitz
8. E. O’Shea

In Molecular Biology

1. Alexander van Oudenaarden
2. Arjun Raj
3. James J. Collins
4. Johan Paulsson
5. Peter S. Swain
6. Paul C. Bressloff
7. Michael B. Elowitz
8. E. O’Shea

In Sociology and Political Science

1. Gal Raz
2. Miguel Angel Muñoz
3. Paul C. Bressloff
4. Carl T. Bergstrom
5. Alexander van Oudenaarden
6. R. Losick
7. Eva Jablonka

Citations in the corpus

• Molecular mechanisms underlying bacterial persisters. (2014, neutral): “, mixture of distinct phenotypes) that confers fitness advantages under specific harmful condition would provide another solution to survive fluctuating environments (Kussell and Leibler, 2005).”
• Phenotypic diversity as an adaptation to environmental uncertainty (2008, background): “Such a connection has in fact been drawn for the simplest models, but a more general correspondence has been elusive (Bergstrom and Lachmann, 2004; Kussell and Leibler, 2005).”
• Flocculation, adhesion and biofilm formation in yeasts (2006, background): “Epigenetic switching also helps cells to proactively anticipate new conditions in fluctuating environments (Kussell and Leibler, 2005).”
• Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution (2009, positive): “This means that adaptation through the inheritance of newly induced epigenetic variants may be very rapid (Jablonka and Lamb 1995, 2005; Kussell and Leibler 2005; Richards 2006; Bossdorf et al. 2008), thus leading to the accumulation of epigenetic variations.”
• Cellular Decision-Making and Biological Noise: From Microbes to Mammals (2011, background): “Theory has also shown that a population of cells capable of random phenotypic switching can have advantage in a fluctuating environment (Kussell and Leibler, 2005; Thattai and van Oudenaarden, 2004; Wolf et al., 2005).”
• Noise in protein expression scales with natural protein abundance (2006, background): “It remains to be understood whether the enhanced noise observed here in stress genes could have been selected for by evolution or whether it is a mere result of lack of constraint on the variability in expression of such gene”
• Colloquium: Criticality and dynamical scaling in living systems (2017, background): “39 Indeed, clonal populations of unicellular organisms such as viruses or bacteria often exhibit phenotypic diversity, which constitutes a sort of “bet-hedging” strategy to cope with unpredictable environmental changes (Kussell and Leibler, 2005; Veening et al., 2008; Wolf et al., 2005).”
• Measuring single-cell gene expression dynamics in bacteria using fluorescence time-lapse microscopy (2011, methodology): “Light source for epifluorescence ; we recommend a 300 W LambdaLS Xenon light source (5).”
• Phenotypic consequences of promoter-mediated transcriptional noise. (2006, background): “Recent theoretical work (Thattai and van Oudenaarden, 2004; Wolf et al., 2005; Kussell and Leibler, 2005) has also shown that heterogeneous, or noisy, population-scale responses to stimuli may be beneficial under fluctuating environmental conditions.”
• Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. (2011, neutral): “Such probabilistic behavior has been shown to be advantageous in certain environmental conditions (Kussell and Leibler, 2005; Thattai and van Oudenaarden, 2004; Wolf et al., 2005).”
• Bistability in bacteria (2006, background): “A recent theoretical analysis suggests that bistability is an optimal strategy for coping with infrequent changes in the environment whereas responding only after a change is sensed is preferred when cells must deal with frequent fluctuations in environmental conditions (Kussell and Leibler, 2005).”
• Stochastic gene expression and its consequences (2008, background): “One idea is that having individual cells stochastically switch between activating or inactivating a metabolic pathway could confer a fitness advantage to the overall population in fluctuating environments (Kussell and Leibler, 2005; Thattai and van Oudenaarden, 2004; Wolf et al., 2005).”
• Stochastic switching in biology: from genotype to phenotype (2017, methodology): “coli due to Kussell and Leibler [160], see also [186].”