Universal physical responses to stretch in the living cell

By X. Trepat, Linhong Deng, S. An, D. Navajas, D. Tschumperlin, W. Gerthoffer, J. Butler, Jeffrey J. Fredberg. Nature, 2007

715 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/cf43788b0ba0cb881eea5e7962150617acf7a9c9

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Citations in the corpus

Physics of adherent cells (2013, methodology): “…reassembly: Recent experimental studies have shown that cell stretch induces CSK fluidization (Bursac et al., 2005; Chen et al., 2010a; Deng et al., 2006; Krishnan et al., 2009; Trepat et al., 2007) which occurs through direct physical effects of physical forces upon weak cytoskeletal crosslinks.”
Mechanical control of stem cell differentiation (2008, background): “On short time scales, the cytoskeleton can fluidize in response to mechanical stretch (Trepat et al., 2007), but cells rapidly transition to an active response in which realignment of the cytoskeleton occurs to counterbalance the applied force (Katsumi et al.”
Biomolecules under mechanical force (2010, background): “Recent studies [429] showed that the response of living cells to stretching is governed by simple phenomenological universal laws, despite the fact that the effects of biochemistry, molecular crowding and physical forces are complex and inseparable.”
Unjamming and cell shape in the asthmatic airway epithelium (2015, background): “…or dysmaturity, the prolonged or sustained hypermobile fluid-like phase defines an unanticipated maladaptive phenotype which, to our knowledge, comprises the first known instance—in any disease—where pathobiology is linked to the recent discovery of cellular jamming and unjamming 4,17,53,54 .”
Investigating the robustness of the classical enzyme kinetic equations in small intracellular compartments (2009, neutral): “It is also found that the total concentration of macromolecules inside both prokaryotic and eukaryotic cells is very large [3,4], of the order of 50-400 mg/ml which implies that between 5% and 40% of the total intracellular volume is physically occupied by these molecules [5].”