Unjamming and cell shape in the asthmatic airway epithelium
By Jin-Ah Park, Jae Hun Kim, Dapeng Bi, Nader Jennifer A. Mitchel, Taheri Qazvini, K. Tantisira, N. Qazvini, C. Park, Maureen McGill, S. Kim and 18 more. Nature Materials, 2015
640 citations recorded by the source corpus.
From coffee beans flowing in a chute to cells remodeling in a living tissue, a wide variety of close‐packed collective systems –both inert and living– have the potential to jam. The collective can sometimes flow like a fluid or jam and rigidify like a solid. The unjammed‐to‐jammed transition remains poorly understood, however, and structural properties characterizing these phases remain unknown. Using primary human bronchial epithelial cells, we show that the jamming transition in asthma is linked to cell shape, thus establishing in that system a structural criterion for cell jamming. Surprisingly, critical scaling collapse predicts a counterintuitive relationship between jamming, cell shape, and cell‐cell adhesive stresses that is borne out by direct experimental observations. Cell shape thus provides a rigorous structural signature for classification and investigation of bronchial epithelial layer jamming in asthma, and potentially in any process in disease or development in which epithelial dynamics play a prominent role.
Subfields: Biomedical Engineering, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/8082c5b3dc6a050eacba2fbeb4bd94071443ef2e
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In Biomedical Engineering
Citations in the corpus
- The statistical physics of active matter: From self-catalytic colloids to living cells (2017, result): “This prediction has found experimental support in experiments on human bronchial epithelial cells [92].”
- Motility-driven glass and jamming transitions in biological tissues (2015, background): “813 works perfectly in identifying a jamming transition in in-vitro experiments involving primary human tissues, where cells are clearly motile (v0 6= 0) [38].”