Damage to the Insula Disrupts Addiction to Cigarette Smoking

By Nasir H. Naqvi, D. Rudrauf, Hanna Damasio, Antoine Bechara. Science, 2007

1,226 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cec7404aecf0b8ac1604789c32cb765eea8f821a

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review (2010, background): “…mechanisms of the prefrontal cortex and subvert attention, reasoning, planning, and decision-making processes away from foreseeing the negative consequences of a given action, and toward formulating plans to seek and procure rewarding stimuli such as drugs cessation (Naqvi et al, 2007).”
Neural substrates of smoking cue reactivity: A meta-analysis of fMRI studies (2011, neutral): “First, some smokers who suffered selective damage to the insula as a result of a stroke were able to quit smoking with ease, and reported that they no longer craved cigarettes (Naqvi et al., 2007).”
Widespread reward-system activation in obese women in response to pictures of high-calorie foods (2008, neutral): “The (rostral) insula, for example, is the location of primary taste cortex (Rolls, 2007), and the insula is also involved in motivational processes (Naqvi et al., 2007; Porubska et al., 2006).”
Exploring the Relationship Between Mindfulness and Cardiac Perception (2013, neutral): “2012) and addiction (Naqvi et al. 2007; see VerdejoGarcia et al. 2012).”
The Neurocircuitry of Impaired Insight in Drug Addiction (2009, neutral): “Insula and anterior cingulate roles in drug addiction A recent study explored the role of insula damage in addiction [ 40 ].”
fMRI Reactivity to High-Calorie Food Pictures Predicts Short- and Long-Term Outcome in a Weight-Loss Program (2012, background): “The striatum and insula have also been implicated in both food and drug craving (Garavan et al., 2000; Garavan, 2010; Naqvi et al., 2007; Naqvi and Bechara, 2010; Pelchat et al., 2004).”
Hedonic Hotspots: Generating Sensory Pleasure in the Brain (2007, neutral): “Insular cortex has been suggested to perhaps be especially important for mediating learned likes for initially aversive stimuli, such as the taste of cigarette smoke (Naqvi et al., 2007), and also for learned dislikes such as nausea-induced taste aversions or pictures of rotten foods (Gutierrez et a”
Pro v Con Reviews: Is Food Addictive? (2012, background): “The importance of the insula has been highlighted by a study that reported that smokers with damage to this region (but not smokers who had suffered extra-insular lesions) were able to stop smoking easily and without experiencing either cravings or relapse (134).”
Resting state functional connectivity in addiction: Lessons learned and a road ahead (2012, background): “Critically, damage to the insula can result in a sudden and profound disruption of smoking behavior (Naqvi et al., 2007).”
Human Insula Activation Reflects Risk Prediction Errors As Well As Risk (2008, background): “Specifically, insula activation has been reported for a wide variety of negatively and positively valenced affective processes, including integration of body states and emotions (interoception) (Mesulam, 1998), hunger (Craig, 2002), craving and addiction (Naqvi et al., 2007), empathy for pain (Singe”
Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics (2009, background): “Smokers who acquire damage to the insula (for example, due to brain trauma) are more likely to quit smoking soon after the injury, are more likely to remain abstinent, and are less likely to experience conscious urges to smoke compared with smokers with brain injury that does not affect the insula (”