Polymer nanogels: a versatile nanoscopic drug delivery platform

By Reuben T. Chacko, J. Ventura, Jiaming Zhuang, S. Thayumanavan. Advanced Drug Delivery Reviews, 2012

561 citations recorded by the source corpus.

In this review we put the spotlight on crosslinked polymer nanogels, a promising platform that has the characteristics of an “ideal” drug delivery vehicle. Some of the key aspects of drug delivery vehicle design like stability, response to biologically relevant stimuli, passive targeting, active targeting, toxicity and ease of synthesis are discussed. We discuss several delivery systems in this light and highlight some examples of systems, which satisfy some or all of these design requirements. In particular, we point to the advantages that crosslinked polymeric systems bring to drug delivery. We review some of the synthetic methods of nanogel synthesis and conclude with the diverse applications in drug delivery where nanogels have been fruitfully employed.

Subfields: Biomaterials, Molecular Medicine, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/cb41f7c763d441a5a907cdc380063a4e7484f2f7

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In Biomaterials

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2. T. Bronich
3. S. Desale

Citations in the corpus

• Nanogels: an overview of properties, biomedical applications and obstacles to clinical translation (2015, background): “The versatility of their architecture allows for incorporation of a plethora of guest molecules ranging from inorganic nanoparticles to biomacromolecules like proteins and DNA with suitable modifications of the materials used for their construction, without compromising their gel-like behavior [10-1”