B Cell Responses: Cell Interaction Dynamics and Decisions.

By J. Cyster, Christopher D. C. Allen. Cell, 2019

802 citations recorded by the source corpus.

B cells and the antibodies they produce have a deeply penetrating influence on human physiology. Here, we review current understanding of how B cell responses are initiated; the different paths to generate short- and long-lived plasma cells, germinal center cells, and memory cells; and how each path impacts antibody diversity, selectivity, and affinity. We discuss how basic research is informing efforts to generate vaccines that induce broadly neutralizing antibodies against viral pathogens, revealing the special features associated with allergen-reactive IgE responses and uncovering the antibody-independent mechanisms by which B cells contribute to health and disease.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/ce9fc07c7f8a01a35077594d4eba0805528677f8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Alessandro Sette
2. Shane Crotty

Citations in the corpus

• Adaptive immunity to SARS-CoV-2 and COVID-19 (2021, positive): “, 2020), consistent with extended germinal center responses after a viral infection (Cyster and Allen, 2019).”