Efflux-Mediated Drug Resistance in Bacteria

By Xian-Zhi Li, H. Nikaido. Drugs, 2012

1,064 citations recorded by the source corpus.

Subfields: Molecular Biology, Molecular Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/ce935c52ee3e900dedbb7a812f59e7687f5acf72

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Molecular Medicine

In Pharmacology

Citations in the corpus

Antibiotic resistance and persistence—Implications for human health and treatment perspectives (2020, positive): “Generally, it is difficult to find new substances against Gram-negative bacteria as they evolved an outer membrane that protects them from unwanted compounds (Li & Nikaido, 2004; Payne et al , 2007).”
Efflux-Mediated Drug Resistance in Bacteria: an Update (2009, background): “AcrB transporter is a homotrimer and characteristically contains a large periplasmic domain that equals the transmembrane domain in size.([1,38]) When AcrB protein was co-crystallized with drugs, dyes or deoxycholate, the ligands were found not only on the wall of the central cavity of the transmemb”
Bacterial multidrug efflux pumps: mechanisms, physiology and pharmacological exploitations. (2014, background): “Depending on the specific classes they belong to, efflux pumps are either single-component transporters or multiple-component systems containing not only an inner membrane transporter, but also an outer membrane channel and a periplasmic adaptor protein, such as the RND type efflux pumps [5].”
Tetracycline Antibiotics and Resistance. (2016, background): “MarA is a key activator of stress-responsive genes, and its role in promoting overexpression of the major multidrug efflux pump, AcrAB (Li and Nikaido 2009), is central to conferring an MDR phentoype in enteric bacteria (Gambino et al. 1993; Alekshun and Levy 1997).”
Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents (2017, background): “coli), Enterobacteraerogenes and Klebsiella pneumonia, the efflux pump slows down the penetration of hydrophilic solutes that decrease the transmembrane diffusion of lipophilic solutes by down-regulating the ‘porin’ production [70, 71].”