Cell signaling. H2O2, a necessary evil for cell signaling.

By S. Rhee. Science, 2006

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Mitochondrial complex III ROS regulate adipocyte differentiation (2011, unknown): “Hydrogen peroxide is the major form of ROS that triggers redox-dependent signaling in the cytosol (Rhee, 2006).”
Redox-based regulation of signal transduction: principles, pitfalls, and promises. (2008, background): “inhibition of signaling induced by PDGF, TNFα, or ceramide, suggesting that Prx enzymes contribute to signaling by removing H2O2 [3,50].”
Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling (2018, unknown): “The active site of PTPs contains an essential cysteine residue that is in the thiolate anion form (Cys-S−) at neutral pH and is therefore highly susceptible to oxidation (Tonks, 2005; Rhee, 2006).”
Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases (2011, unknown): “…proliferation, migration, etc .) via oxidation of signaling molecules (Akt, Src, PLCs, MAPK, etc .) or via oxidative inactivation of protein tyrosine phosphatases (PTPs), thereby promoting tyrosine phosphorylation-mediated redox signaling or regulating protein function (193, 218, 224).”
The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology (2012, background): “For example, figure 7 (following Rhee [69]) illustrates one view of the role of intracellular H2O2 signalling.”