Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts.

By K. Mchugh, K. Hodivala-Dilke, M. Zheng, N. Namba, Jonathan D. Lam, D. Novack, Xunqiang Feng, F. Ross, R. Hynes, S. Teitelbaum. Journal of Clinical Investigation, 2000

762 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Molecular Biology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/ce3cf9d6b9231df292477cefd3d304280777a9a1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology and Allergy

1. F. Ross
2. E. Danen
3. S. Huveneers
4. P. Robey

In Molecular Biology

1. S. Teitelbaum
2. F. Ross
3. S. Gronthos
4. S. Wei
5. Ping Zhou
6. H. Kitaura
7. A. Mildner
8. Steffen Jung

In Rheumatology

1. S. Gronthos
2. P. Robey

Citations in the corpus

• TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. (2000, methodology): “Recombinant murine RANKL was prepared as a fusion protein with glutathione S-transferase, as we have previously described (13), and lack of endotoxin contamination was confirmed by limulus amoebocyte lysate assay (BioWhittaker Inc.”
• Macrophages: development and tissue specialization. (2015, background): “Osteoclast polarization is also controlled by integrin αvβ3-mediated adhesion and signaling (162), the tyrosine kinase c-Src (163), and microRNA circuits (164).”
• Adhesion signaling – crosstalk between integrins, Src and Rho (2009, background): “…and Src in platelets, integrin-αvβ3-mediated Src activation regulates the function of osteoclasts during bone resorption. β3integrin-deficient or Src-deficient mice display partially overlapping abnormalities that are caused by defective bone remodeling (McHugh et al., 2000; Soriano et al., 1991).”
• IL-1 mediates TNF-induced osteoclastogenesis. (2005, methodology): “Murine RANKL was expressed in our laboratory as described previously (27).”
• Surface protein characterization of human adipose tissue‐derived stromal cells (2001, background): “In addition, the expression of CD44 and CD146 were con®rmed by Western immunoblotting (Fig.”
• Genetic regulation of osteoclast development and function (2003, background): “It is now clear that the integrin αvβ3 is central to osteoclast/bone recognition, because mice with the β3 gene knocked out have dysfunctional osteoclasts and become progressively osteopetroti”