EMT Transition States during Tumor Progression and Metastasis.

By I. Pastushenko, C. Blanpain. Trends in Cell Biology, 2019

2,439 citations recorded by the source corpus.

Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells acquire mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion, metastasis, and resistance to therapy. Recently, it has been demonstrated that EMT is not a binary process, but occurs through distinct cellular states. Here, we review the recent studies that demonstrate the existence of these different EMT states in cancer and the mechanisms regulating their functions. We discuss the different functional characteristics, such as proliferation, propagation, plasticity, invasion, and metastasis associated with the distinct EMT states. We summarize the role of the transcriptional and epigenetic landscapes, gene regulatory network and their surrounding niche in controlling the transition through the different EMT states.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/ce275400ccc9cdca29f0b97c683989d9122d8557

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Citations in the corpus

Cholangiocarcinoma 2020: the next horizon in mechanisms and management (2020, positive): “Although initially considered as a binary process, it is now well established that epithelial cells undergoing EMT become mesenchymal in a gradual manner, known as partial EMT 178,179 .”
Macrophages in immunoregulation and therapeutics (2023, background): “EMT refers to the process through which epithelial cells acquire mesenchymal characteristics and acquire malignant biological traits such as invasion and metastasis.(313) All through the EMT process, tumor cells give up cell-to-cell intersections and apical-basal polarity because of E-cadherin suppr”
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis (2022, background): “In addition, cells with EMT characteristics can degrade and invade their extracellular matrix at the invasion front of individual cells or populations of cells by activating proteases such as matrix metalloproteinase (MMPs) [41].”
Dynamic EMT: a multi‐tool for tumor progression (2021, positive): “Another group identified different tumor transition states occurring during EMT in cancer progression and introduced the term “hybrid” EMT (Pastushenko et al , 2018; Pastushenko & Blanpain, 2019; Pastushenko et al , 2021) (Fig 1B).”
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments (2023, background): “ECM‐induced EMT: ready for invasion For epithelial cells, EMT is a critical process for tumor progression and metastasis [237].”