Liposome Technology for Industrial Purposes

By A. Wagner, K. Vorauer-Uhl. Journal of Drug Delivery, 2010

422 citations recorded by the source corpus.

Liposomes, spherical vesicles consisting of one or more phospholipid bilayers, were first described in the mid 60s by Bangham and coworkers. Since then, liposomes have made their way to the market. Today, numerous lab scale but only a few large-scale techniques are available. However, a lot of these methods have serious limitations in terms of entrapment of sensitive molecules due to their exposure to mechanical and/or chemical stress. This paper summarizes exclusively scalable techniques and focuses on strengths, respectively, limitations in respect to industrial applicability. An additional point of view was taken to regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.

Subfields: Molecular Biology, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/cdac68c2269d30440398a4f5e3b44c624cc6894d

How researchers see this paper

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In Molecular Biology

1. A. Molinari
2. Giuseppina Bozzuto

In Pharmaceutical Science

1. A. Molinari
2. Giuseppina Bozzuto

Citations in the corpus

• Liposomes as nanomedical devices (2015, methodology): “20 One of the most widely used techniques for liposome-manufacture preparation is the thin-film hydration or Bangham method.”