Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β

By J. Abreu, N. Ketpura, B. Reversade, E. Robertis. Nature Cell Biology, 2002

632 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cd6402ff75927639bec8deb8000e72096b2b6545

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In Molecular Biology

1. David J. Abraham
2. A. Leask

Citations in the corpus

• Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development (2003, background): “Consistent with this, CTGF binds to BMPs and TGFβ, leading to inhibition of BMP and enhancement of TGFβsignaling (Abreu et al., 2002).”
• All in the CCN family: essential matricellular signaling modulators emerge from the bunker (2006, background): “In cultured Xenopus cells, CCN2 binds TGF and enhances the ability of TGF to bind TGF receptors at low TGF concentrations and hence indirectly affects Smad-responsive promoters (Abreu et al., 2002).”