Activation of Integrin αIIbß3 by Modulation of Transmembrane Helix Associations

By Renhao Li, N. Mitra, H. Gratkowski, G. Vilaire, R. Litvinov, Chandrasekaran Nagasami, J. Weisel, J. D. Lear, William F. DeGrado, J. Bennett. Science, 2003

229 citations recorded by the source corpus.

Subfields: Cell Biology, Hematology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/cd55abe6769a9af368b0cb88785f74239b99281c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Valerie M. Weaver
2. M. Humphries
3. Iain D. Campbell
4. Micah Dembo
5. Matthew J. Paszek
6. Pengfei Lu
7. M. Schwartz

In Hematology

1. Valerie M. Weaver
2. M. Humphries
3. Iain D. Campbell

In Immunology and Allergy

1. Valerie M. Weaver
2. Iain D. Campbell
3. M. Humphries
4. Matthew J. Paszek
5. M. Schwartz
6. Pengfei Lu

Citations in the corpus

• Integrin structure, activation, and interactions. (2011, background): “[Note that whereas most evidence supports the heterodimeric form, there is also evidence that homomeric TM oligomers can form in vitro (Li et al. 2003; Parthasarathy et al. 2008); nevertheless, the evidence for homodimeric forms mainly comes from experiments or simulations performed without the…”
• Tensional homeostasis and the malignant phenotype. (2005, background): “…asparagine (V737N), or neutral glycine 744 was replaced with asparagine (G744N), to promote integrin self-association through enhanced hydrogen bonding in the transmembrane domain (Li et al., 2003), and cells expressing the mutant integrins were assayed for their behavior on compliant gels.”