Histone Deacetylases: Unique Players in Shaping the Epigenetic Histone Code

By S. Thiagalingam, Kuang-Hung Cheng, H. Lee, Nora D Mineva, A. Thiagalingam, Jose F. Ponte. Annals of the New York Academy of Sciences, 2003

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Anticancer activities of histone deacetylase inhibitors (2006, background): “The opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs) tightly regulate gene expression through chromatin modificatio”
DNA methylation and cancer. (2004, background): “Histone deacetylase (HDAC) inhibitors are also being tried as potential chemotherapeutic agents.(115) The variants of deoxycytidine act by a number of methods.”
How corticosteroids control inflammation: Quintiles Prize Lecture 2005 (2006, background): “…of histone that is associated with increased expression of inflammatory genes is counteracted by the activity of HDACs, of which 11 that deacetylate histones are now British Journal of Pharmacology vol 148 (3) identified in mammalian cells (de Ruijter et al., 2003; Thiagalingam et al., 2003).”