International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.

By B. Khakh, G. Burnstock, C. Kennedy, B. King, R. North, P. Séguéla, M. Voigt, P. Humphrey. Pharmacological Reviews, 2001

678 citations recorded by the source corpus.

ATP acts as a humoral mediator to control cell function extracellularly. The receptors that mediate the actions of ATP belong to two classes, the metabotropic P2Y receptors and the transmitter-gated, ion channel P2X receptors. This review describes the structure, distribution, function, and ligand recognition characteristics of P2X receptors, which comprise seven distinct subunits that can function as both homo- and hetero- polymers. The pharmacology of P2X receptors is complicated by marked differences between species orthologues. The current nomenclature is based largely on recombinant receptor studies and detailed knowledge of endogenous P2X receptors in native tissues is limited because of lack of good selective agonists and antagonists for each receptor type.

Subfields: Endocrine and Autonomic Systems, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/cd359f6f451ec922724041dc33378770c43beb4b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. G. Burnstock
2. G. Knight

In Physiology

1. G. Burnstock
2. G. Knight
3. W. Junger
4. H. Zimmermann
5. Guo-Yuan Yang
6. Yongting Wang
7. Jixian Wang
8. Yuanyuan Ma

In Psychiatry and Mental health

1. G. Burnstock

Citations in the corpus

• International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update (2008, background): “They differ in structure from two additional LGIC families: the tetrameric glutamate receptors (P2X) (Chen and Wyllie, 2006) and the trimeric purine receptors (Khakh et al., 2001; Khakh and North, 2006).”
• Cellular distribution and functions of P2 receptor subtypes in different systems. (2004, background): “The stoichiometry of P2X1–7 receptors is thought to involve three subunits that form a stretched trimer (Khakh et al., 2001).”