Laminar structure of spontaneous and sensory-evoked population activity in auditory cortex

By Shuzo Sakata, Kenneth D. Harris. Neuron, 2009

614 citations recorded by the source corpus.

Summary Spontaneous activity plays an important role in the function of neural circuits. Although many similarities between spontaneous and sensory-evoked neocortical activity have been reported, little is known about consistent differences between them. Here, using simultaneously recorded cortical populations and morphologically identified pyramidal cells, we compare the laminar structure of spontaneous and sensory-evoked population activity in rat auditory cortex. Spontaneous and evoked patterns both exhibited sparse, spatially localized activity in layer 2/3 pyramidal cells, with densely distributed activity in larger layer 5 pyramidal cells and putative interneurons. However, the propagation of spontaneous and evoked activity differed, with spontaneous activity spreading upward from deep layers and slowly across columns, but sensory responses initiating in presumptive thalamorecipient layers, spreading rapidly across columns. The similarity of sparseness patterns for both neural events, and distinct spread of activity may reflect similarity of local processing, and differences in the flow of information through cortical circuits, respectively.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/cd1b6cf9b75bf9af2d7751378ddfcb1385c29477

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Reconstruction and Simulation of Neocortical Microcircuitry. (2015, background): “, 2004; Singer, 1993), and the functional impact of individual neurons across cortical layers (Sakata and Harris, 2009; Schroeder and Foxe, 2002; Silva et al., 1991; Steriade et al., 1993), as well as in vivo activity in somatosensory and other cortical areas (Chen et al.”
Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex (2010, neutral): “, 2010) cortices do not contain precise maps of odors or tones, respectively, and the suspected GABAergic neurons in these areas are also more broadly tuned for those features than excitatory neurons (Poo and Isaacson, 2009; Sakata and Harris, 2009).”
Cortical membrane potential signature of optimal states for sensory signal detection (2015, background): “In the auditory cortex, depth of anesthesia affects pyramidal cell sensory-evoked responses and spontaneous activity differentially between cortical layers (Sakata and Harris, 2009), and the actions of neuromodulatory transmitters are layer and cell type specific (McCormick, 1992).”
Canonical microcircuits for predictive coding. (2012, positive): “This issue is important as distinct neuronal dynamics in different cortical layers are becoming increasingly apparent (de Kock et al., 2007; Sakata and Harris, 2009; Maier et al., 2010; Bollimunta et al., 2011).”
Neural syntax: cell assemblies, synapsembles and readers (2010, neutral): “Since assembly members are typically drawn from sparsely firing neurons of a large neuron network (Fujisawa et al., 2008; Harris et al., 2003; Sakata and Harris, 2009), only a few principal cells are typically active in a given volume of tissue at any given time.”
Predictive Processing: A Canonical Cortical Computation (2018, neutral): “In the neocortex, and particularly in layer 2/3, the baseline firing rates of principal neurons are much lower (de Kock et al., 2007; Niell and Stryker, 2008; Sakata and Harris, 2009), bidirectional modulation of activity is less plausible.”
The Encoding of Speech Sounds in the Superior Temporal Gyrus (2019, neutral): “…recurrent connections form the foundation of local microcircuits that represent sounds as functional units (Atencio and Schreiner, 2016; Sakata and Harris, 2009; See et al., 2018), in which superficial layers exhibit substantially more fine-tuned, flexible, and complex receptive field properties…”
Distinct laminar origins of sensory-evoked high-gamma and low-frequency ECoG signals revealed by optogenetics (2026, unknown): “These differences in spiking statistics are conserved across cortical areas and species (14, 45, 47–49), and will likely have important consequences for extra-cellular field generation.”
Distinct laminar origins of high-gamma and low-frequency ECoG signals revealed by optogenetics (2025, unknown): “These differences in spiking statistics are conserved across cortical areas and species 14,45,47– 49 , and have important consequences for extracellular field generation.”