Post-Synthetic Modifications of Iron-Carboxylate Nanoscale Metal-Organic Frameworks for Imaging and Drug Delivery

By K. Taylor-Pashow, J. D. Rocca, Zhigang Xie, S. Tran, Wenbin Lin. Journal of the American Chemical Society, 2009

1,350 citations recorded by the source corpus.

Fe(III)-carboxylate nanoscale metal-organic frameworks (NMOFs) with the MIL-101 structure were synthesized using a solvothermal technique with microwave heating. The ~200 nm particles were characterized using a variety of methods, including SEM, PXRD, nitrogen adsorption measurements, TGA, and EDX. By replacing a percentage of the bridging ligand (terephthalic acid) with 2-amino terephthalic acid, amine groups were incorporated into the framework to provide sites for covalent attachment of biologically relevant cargoes while still maintaining the MIL-101 structure. In proof-of-concept experiments, an optical contrast agent (a BODIPY dye) and an ethoxysuccinato-cisplatin anticancer prodrug were successfully incorporated into the Fe(III)-carboxylate NMOFs via post-synthetic modifications of the as-synthesized particles. These cargoes are released upon the degradation of the NMOF frameworks, and the rate of cargo release was controlled by coating the NMOF particles with a silica shell. Potential utility of the new NMOF-based nano-delivery vehicles for optical imaging and anticancer therapy were demonstrated in vitro using HT-29 human colon adenocarcinoma cells.

Subfields: Biomaterials, Biomedical Engineering, Inorganic Chemistry

View Paper: https://www.semanticscholar.org/paper/cd09c6d334bda4316227db8178f454a6208dfbef

How researchers see this paper

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In Biomedical Engineering

1. Jinhua Li
2. Lingxin Chen

In Inorganic Chemistry

1. Jinhua Li
2. Lingxin Chen
3. Yingying Wen
4. Dongyan Liu

Citations in the corpus

• Recent advances in solid-phase sorbents for sample preparation prior to chromatographic analysis (2014, background): “Moreover, the promising MOFs, which offer a variety of topologies, porous networks, high surface areas, nanoscale porosity, tunable pore sizes, in-pore functions, and outsurface modification, have potential for the applications of catalysis [55], separation [54,56], gas storage [57] and drug deliver”
• Metal-Organic Frameworks as Potential Drug Carriers (2010, neutral): “Recently, the Lin group reported loading and release of biomedical agents in nanoMIL-101(Fe) [41].”