Apoptosis Regulates Human Vascular Calcification In Vitro: Evidence for Initiation of Vascular Calcification by Apoptotic Bodies

By D. Proudfoot, J. Skepper, L. Hegyi, M. Bennett, C. Shanahan, P. Weissberg. Circulation Research, 2000

745 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles. (2012, background): “In this context, VSMCs could acquire an osteoblastic phenotype.(92)”
Medial vascular calcification revisited: review and perspectives. (2014, background): “It appears that while deposition of hydroxyapatite represents the resulting commonality of VC, different initiating and propagating molecular mechanisms, as well as diverse crystalline compositions of calcium apatite crystals may be present in various forms of VC.4–6 For example, it seems likely tha”
Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. (2004, methodology): “In vitro vesicle calcification assays were performed in triplicate over 24 h using a standard calcifying buffer and 4 to 15 g of VSMC-derived MV or AB as described previously (10).”
Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness (2018, background): “Apoptosis promotes matrix calcification, primarily through the release of the calcifying membrane-bound MVs, such as apoptotic bodies,(113) acting as nucleation sites of calcification in blood vessels.(68,113) Vesicles isolated from normal arteries are less efficient in accumulating calcium compared”