Nanomaterials Based on DNA

By Nadrian C. Seeman. 2010

945 citations recorded by the source corpus.

The combination of synthetic stable branched DNA and sticky ended cohesion has led to the development of structural DNA nanotechnology over the past 30 years. The basis of this enterprise is that it is possible to construct novel DNA-based materials by combining these features in a self-assembly protocol. Thus, simple branched molecules lead directly to the construction of polyhedra whose edges consist of double helical DNA, and whose vertices correspond to the branch points. Stiffer branched motifs can be used to produce self-assembled two-dimensional and three-dimensional periodic lattices of DNA (crystals). DNA has also been used to make a variety of nanomechanical devices, including molecules that change their shapes, and molecules that can walk along a DNA sidewalk. Devices have been incorporated into two-dimensional DNA arrangements; sequence-dependent devices are driven by increases in nucleotide pairing at each step in their machine cycles.

Subfields: Ecology, Molecular Biology

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Citations in the corpus

Programmable chemical controllers made from DNA (2013, methodology): “Events of perfect cultural transmission and innovations should be more frequent in a large population 4 .”
A primer to scaffolded DNA origami (2011, background): “The interhelix connections are typically formed by antiparallel cross-overs 35,36 of either the staple or scaffold strand from one DNA double-helical domain to a neighboring one ( Fig.”
Programmable materials and the nature of the DNA bond (2015, background): “and form much of the basis for what is called “structural DNA nanotechnology” [Summary figure, (A)] (12).”
Dynamic DNA nanotechnology using strand-displacement reactions. (2011, background): “Structural DNA nanotechnology has achieved the construction of two- and three-dimensional objects of varying sizes and complexity using 'bottom-up' DNA self-assembly, and has culminated in the development of macroscopic materials with nanometre-scale addressabilit”
The Emerging Field of RNA Nanotechnology (2010, positive): “The advantages of RNA nanomedicine include: (1) self-assembly (see ‘Techniques for constructing RNA nanoparticles’ section for self-assembly and self-processing in vivo); (2) multivalency; (3) targeted delivery; (4) protein-free; (5) nanoscale size; (6) controlled synthesis with defined structure an”