Chloroquine Resistance in Plasmodium falciparum Malaria Parasites Conferred by pfcrt Mutations

By A. Sidhu, D. Verdier-Pinard, David A. Fidock. Science, 2002

766 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/cc6cc17aa4ce40d5c456121a8b50c2cc127a477b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Computational Theory and Mathematics

1. David A. Fidock

In Public Health, Environmental and Occupational Health

1. Simon L. Croft
2. David A. Fidock

Citations in the corpus

• Antimalarial drug discovery: efficacy models for compound screening (2004, background): “falciparum with plasmids expressing either positive or negative selectable markers, and to thereby alter, replace or knock out genes of interes”
• Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. (2000, background): “The finding that L272F PfCRTDd2 does not confer BSD resistance when expressed in Dd2 parasites suggests that either (1) PfCRTDd2 is already a poor transporter of BSD (noting that the 3D7 and Dd2 haplotypes of PfCRT differ by eight mutations) and a reduction in this meager transport activity by the i”
• A Systematic Map of Genetic Variation in Plasmodium falciparum (2006, unknown): “27) (four SFPs/36 probes; 11% SFP rate) [46].”