Autophagy and Metabolism
By Joshua D. Rabinowitz, E. White. Science, 2010
1,137 citations recorded by the source corpus.
Autophagy is a process of self-cannibalization. Cells capture their own cytoplasm and organelles and consume them in lysosomes. The resulting breakdown products are inputs to cellular metabolism, through which they are used to generate energy and to build new proteins and membranes. Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however—cancer cells exploit it to survive in nutrient-poor tumors.
Subfields: Cell Biology, Epidemiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/cc06a8cc5527322638f01e1d3345ac3e115fd28b
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Citations in the corpus
- Autophagy and autophagy-related proteins in cancer (2020, background): “Autophagy functioning as a cancer promotion mechanism is mainly based on its role involved in removing damaged mitochondria, inhibiting DNA damage, maintaining genome stability, limiting inflammation, and finally preventing cancer cell damage under the conditions of stress [14, 213, 232].”
- Links between metabolism and cancer. (2012, background): “Additionally, AMPK-mediated phosphorylation of ULK-1 triggers autophagy, which recycles cellular components for energy production (Rabinowitz and White 2010; Singh and Cuervo 2011).”
- Otto Warburg's contributions to current concepts of cancer metabolism (2011, background): “This pivotal conceptual framework of bioenergetic supply and demand suggests that cancer cells are addicted to the Warburg effect, and nutrient deprivation should trigger an autophagic response, which, if unsustainable, would result in cancer cell deat”
- The Roles of Autophagy in Cancer (2018, background): “In addition, autophagy fulfills the high metabolic and energetic demands of proliferating tumors by recycling intracellular components to supply metabolic substrates [75,76].”
- Copper metabolism in cell death and autophagy (2023, background): “mine the selectivity of autophagic degradation of cargo [174].”