Seroepidemiology of Human Polyomaviruses

By Jaime M. Kean, Suchitra Rao, Michael Wang, R. Garcea. PLoS Pathogens, 2009

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In addition to the previously characterized viruses BK and JC, three new human polyomaviruses (Pys) have been recently identified: KIV, WUV, and Merkel Cell Py (MCV). Using an ELISA employing recombinant VP1 capsid proteins, we have determined the seroprevalence of KIV, WUV, and MCV, along with BKV and JCV, and the monkey viruses SV40 and LPV. Soluble VP1 proteins were used to assess crossreactivity between viruses. We found the seroprevalence (+/− 1%) in healthy adult blood donors (1501) was SV40 (9%), BKV (82%), JCV (39%), LPV (15%), KIV (55%), WUV (69%), MCV strain 350 (25%), and MCV strain 339 (42%). Competition assays detected no sero-crossreactivity between the VP1 proteins of LPV or MCV or between WUV and KIV. There was considerable sero-crossreactivity between SV40 and BKV, and to a lesser extent, between SV40 and JCV VP1 proteins. After correcting for crossreactivity, the SV40 seroprevalence was ∼2%. The seroprevalence in children under 21 years of age (n = 721) for all Pys was similar to that of the adult population, suggesting that primary exposure to these viruses likely occurs in childhood.

Subfields: Electrical and Electronic Engineering, Oncology

View Paper: https://www.semanticscholar.org/paper/cc0422ca24c6b1ac660bc9f09e9493271173c01a

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Citations in the corpus

Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors. (2009, background): “, who also included preabsorption studies [40 – 42].”
Identification of a Novel Polyomavirus from Patients with Acute Respiratory Tract Infections (2007, background): “BK and JC viruses are ubiquitous worldwide, and in adult populations, seroprevalence rates approaching 75% and 100%, respectively, have been reported [10].”