Human memory T cells: generation, compartmentalization and homeostasis

By D. Farber, N. Yudanin, N. Restifo. Nature reviews. Immunology, 2013

866 citations recorded by the source corpus.

Memory T cells constitute the most abundant lymphocyte population in the body for the majority of a person's lifetime; however, our understanding of memory T cell generation, function and maintenance mainly derives from mouse studies, which cannot recapitulate the exposure to multiple pathogens that occurs over many decades in humans. In this Review, we discuss studies focused on human memory T cells that reveal key properties of these cells, including subset heterogeneity and diverse tissue residence in multiple mucosal and lymphoid tissue sites. We also review how the function and the adaptability of human memory T cells depend on spatial and temporal compartmentalization.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/cbb1ce7cd80a74ecba0a3c4e10a0d497b8af5405

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In Immunology

Citations in the corpus

Mechanisms of resistance to immune checkpoint inhibitors (2018, background): “…control), a subset of effector T cells must differentiate into effector memory T cells (TEM) (Ribas et al, 2016b), under the guidance of CD4þ helper T cells and dendritic cells; these are maintained for life and respond to re-challenge with antigen (Harty and Badovinac, 2008; Farber et al, 2014).”
Quantifying memory CD8 T cells reveals regionalization of immunosurveillance (2015, background): “…the C-type lectin CD69 has become the defining marker for distinguishing TRM from recirculating TEM because it antagonizes the sphingosine 1-phosphate receptor 1 (SIPR1) that promotes egress via lymphatics and is necessary for TRM maintenance in epidermis (Farber et al., 2014; Mackay et al., 2013).”
mRNA Vaccines Induce Durable Immune Memory to SARS-CoV-2 and Variants of Concern (2021, background): “In such cases, memory B and T cells can be rapidly reactivated, resulting in the enhanced control of initial viral replication and limiting viral dissemination in the host (24, 25).”
Mapping the Diversity of Follicular Helper T Cells in Human Blood and Tonsils Using High-Dimensional Mass Cytometry Analysis. (2015, background): “Human memory CD4+ T cells have been shown to increase in frequency over time in both blood and tissues due to constant antigen exposure (Farber et al., 2014).”