Molecular mechanisms controlling actin filament dynamics in nonmuscle cells.

By Thomas D. Pollard, L. Blanchoin, R. Mullins. Annual Review of Biophysics and Biomolecular Structure, 2000

1,559 citations recorded by the source corpus.

Subfields: Biophysics, Cell Biology

View Paper: https://www.semanticscholar.org/paper/cb991db18ffc3d6c308a4df2a679a2b0254f4333

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biophysics

1. Liqun Luo
2. A. Ridley

In Cell Biology

1. P. Chiarugi
2. M. Parri
3. A. Ridley
4. C. Hoogenraad
5. Pirta Hotulainen
6. C. Jamora
7. Elaine Fuchs
8. Liqun Luo

Citations in the corpus

• Neural remodeling in retinal degeneration. (2003, background): “A great deal is now known about the extracellular, membrane-dependent, and cytoskeletal signals that determine cell shape, process extension and cell migration (Chiu et al., 2000; Li et al., 2000; Pollard et al., 2000; Condic, 2001; Pollard et al., 2001; Hutson and Chien, 2002).”
• Mechanism of filopodia initiation by reorganization of a dendritic network (2003, background): “The current model for lamellipodial dynamics (Borisy and Svitkina, 2000; Pollard et al., 2000) suggests that treadmilling of the branched actin filament array consists of repeated cycles of dendritic nucleation, elongation, capping, and depolymerization of filaments.”
• Actin dynamics, architecture, and mechanics in cell motility. (2014, background): “Profilin functions by inhibiting the spontaneous formation of actin dimers or trimers, the building blocks for the nucleation of new actin filaments (244).”
• Actin in dendritic spines: connecting dynamics to function (2010, background): “Profilins change actin nucleotide from ADP to ATP to promote barbedend polymerization (Pollard et al., 2000).”
• Rho GTPases and cell migration. (2001, background): “3; Pollard et al., 2000).”
• Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity. (2002, background): “There are other important pathways leading from receptors to the cytoskeleton (for a recent comprehensive review, see Song & Poo 2001).”
• The many faces of actin: matching assembly factors with cellular structures (2007, background): “We ask one basic question in this review: how are filaments assembled for these structures? Actin filament nucleation is unfavourable; therefore, nucleation factors are required to initiate assembly of any actin-based structur”
• The role of the Rho GTPases in neuronal development. (2005, background): “In mammalian cells, a large proportion of actin monomer is bound to Profilin, preventing spontaneous nucleation and the addition of actin monomer to the pointed end of the filament, but not to the barbed end (Pollard et al. 2000).”
• Rac and Rho GTPases in cancer cell motility control (2010, background): “Lamellipodium extension at the leading edge involves actin polymerization, and it is known that lamellipodia consist of branched or unbranced filament networks formed through the actin-nucleating activity of the actin-related proteins 2/3 (Arp2/3) protein complex [27,28].”