Separating the Brain Regions Involved in Recollection and Familiarity in Recognition Memory

By Andrew P. Yonelinas, Leun J. Otten, K. Shaw, Michael D. Rugg. Journal of Neuroscience, 2005

858 citations recorded by the source corpus.

The neural substrates of recognition memory retrieval were examined in a functional magnetic resonance imaging study designed to separate activity related to recollection from that related to continuous variations in familiarity. Across a variety of brain regions, the neural signature of recollection was found to be distinct from familiarity, demonstrating that recollection cannot be attributed to familiarity strength. In the prefrontal cortex, an anterior medial region was related to recollection, but lateral regions, including the anterior and dorsolateral prefrontal cortex, were related to familiarity. Along the lateral parietal cortex, two functionally distinct regions were also observed: a lateral parietal/temporal region related to recollection and a more superior parietal region involved in familiarity. Similarly, in medial parietal regions, the posterior cingulate was related to recollection, whereas the precuneus was related to familiarity. The hippocampus was related to recollection, but also exhibited an inverse relationship to familiarity-driven recognition confidence. The results indicate that recollection and familiarity rely on different networks of brain regions and provide insights into the functional roles of different regions involved in episodic recognition memory.

Subfields: Cognitive Neuroscience, Developmental and Educational Psychology

View Paper: https://www.semanticscholar.org/paper/cb7853d14ddb0fdc1fdf1186bb8cf16b141c8b94

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

In Developmental and Educational Psychology

Citations in the corpus

Imaging recollection and familiarity in the medial temporal lobe: a three-component model. (2007, background): “Yonelinas et al. [ 25 ] 1‐4R Words Re R>4 b l None”
Parietal Cortex and Episodic Memory: An Attentional Account (2008, background): “Although several authors have suggested that dorsal and ventral parietal regions have distinct roles in episodic retrieva”
Brain Networks Underlying Episodic Memory Retrieval (2012, neutral): “to be segregated by the strength of the underlying familiarity signal [5,55].”
Perirhinal cortex supports encoding and familiarity-based recognition of novel associations. (2008, methodology): “In contrast, it has been suggested that the perirhinal cortex (PRc), a region in the anterior parahippocampal gyrus, encodes representations of specific items in a manner that can support familiarity or item memory strength (Aggleton and Brown, 1999; Norman and O’Reilly, 2003; Yonelinas et al., 2005”
Cognitive neuroscience of emotional memory (2006, background): “These two retrieval processes rely on different cognitive and neural mechanism”
The medial temporal lobe and memory (2007, background): “Hippocampal activation has also been differentially associated with high-confidence recognition decisions (Yonelinas et al., 2005), which some have argued reflect recollection-based recognition (Yonehnas, 1994, 1999; YoneHnas et a l , 1996, 1998; c.”
Item, context and relational episodic encoding in humans. (2006, background): “Furthermore, there is a wealth of findings, not reviewed here, demonstrating hippocampal activation during episodic retrieval that differentially correlates with relational memory [10 ,21,43,44,45 ,46–50] (interestingly, evidence for differential perirhinal and hippocampal retrieval mechanisms is no”
The medial temporal lobe and recognition memory. (2007, background): “A number of studies (Daselaar et al. 2006, Montaldi et al. 2006, Ranganath et al. 2003, Yonelinas et al. 2005) have used graded confidence ratings to identify regions where encoding- or retrieval-related activity increases or decreases monotonically with recognition confidence.”
The Brain's Default Network (2008, background): “Furthermore, activity within the medial temporal lobe subsystem increases during retrieval of strong memory traces that include remembered associations and content details (Henson et al. 1999, Eldridge et al. 2000, Wheeler & Buck-ner 2004, Yonelinas et al. 2005).”
Event-related potentials and recognition memory. (2007, neutral): “Findings of direct functional parallels between these fMRI and ERP old/new effects [ 21 ,32,34,53,61,62] give additional credence to the hypothesis that the ERP effect reflects activity in a recollection-sensitive region of the lateral parietal cortex.”
The recognition heuristic: A decade of research (2011, result): “For mere recognition judgments, activation in the precuneus, an area that is known from independent studies to respond to recognition conﬁdence, was observed (Yonelinas, Otten, Shaw, & Rugg, 2005).”