Regulation of metabolism by the innate immune system

By D. Lackey, Jerrold M. Olefsky. Nature Reviews Endocrinology, 2016

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Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease (2019, background): “This is characterized by a polarization of adipose tissue macrophages towards the M1-like phenotype and increased proinflammatory cytokine production (Castoldi et al., 2015; Lackey and Olefsky, 2016; Shapouri-Moghaddam et al., 2018).”
Macrophage plasticity, polarization, and function in health and disease (2018, background): “Recent evidences show the importance of metabolism in shaping the functional phenotype of macrophages in response to distinct polarizing stimuli (Biswas & Mantovani, 2012; Lackey & Olefsky, 2016).”
Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. (2017, unknown): “It is recognized that chronic tissue inflammation with proinflammatory macrophage accumulation, particularly in adipose tissue and liver, is an important feature of obesity-induced insulin resistance (Lackey and Olefsky, 2016) and several soluble macrophage-derived factors have been identified which”
Phagocytosis: An Immunobiologic Process. (2016, background): “…aspects of phagocytosis, should be integrated with current metabolomics (O’Neill and Pearce, 2016), and we still lack knowledge of the Immunity 44, March 15, 2016 ª2016 Elsevier Inc. 471 relationships between mononuclear phagocytes and other cells, such as adipocytes (Lackey and Olefsky, 2016).”