Tissue-resident memory T cells: local specialists in immune defence

By Scott N. Mueller, Laura K. Mackay. Nature reviews. Immunology, 2015

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CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin (2017, neutral): “…to activation with heterogeneous cytokine responses (Naik et al., 2015; Sanchez Rodriguez et al., 2014; Schlapbach et al., 2014; Watanabe et al., 2015) Despite their protective role in recurrent viral infections, direct proof of Trm cell-mediated cytotoxicity is lacking (Mueller and Mackay, 2016).”
Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites (2017, background): “…of tissue-resident memory T cells (TRMs) inmultiple sites, including lungs, intestines, skin, liver, brain, and other mucosal surfaces (for reviews, see Mueller and Mackay, 2016; Schenkel and Cell Report This is an open access article under the CC BY-N Masopust, 2014; Thome and Farber, 2015).”
Human T cell development, localization, and function throughout life (2018, background): “…in diverse types of tissues including barrier sites, mucosal tissues, liver, salivary glands, and brain, where they are retained and do not recirculate as shown by parabiosis and in vivo labeling studies (Jiang et al., 2012; Mueller and Mackay, 2016; Steinert et al., 2015; Teijaro et al., 2011).”