The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance

By P. Bouwman, J. Jonkers. Nature Reviews. Cancer, 2012

607 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Machine learning approaches to drug response prediction: challenges and recent progress (2020, background): “Furthermore, studies suggest that secondary alterations to DNA damage response proteins can shift the response from the error-prone Non-Homologous End Joining pathway to HR, reducing sensitivity to DNA damaging agents 57 .”
Mechanisms of DNA damage, repair and mutagenesis (2017, positive): “VC 2017Wiley Periodicals, Inc. Environmental andMolecular Mutagenesis 58:235^263 (2017) deregulated, which increases mutagenesis and genomic instability, thereby promoting cancer progression [Bouw- man and Jonkers, 2012; Ghosal and Chen, 2013; Wolters and Schumacher, 2013].”
DNA damage sensing by the ATM and ATR kinases. (2013, background): “Importantly, as exemplified by the use of PARP inhibitors in the treatment of BRCA-deficient breast and ovarian cancers, inhibition of specific DDRs may confer “synthetic lethality” to the cancer cells with specific types of genomic instability (Bouwman and Jonkers 2012).”