Top-down suppression deficit underlies working memory impairment in normal aging

By Adam Gazzaley, Jeffrey W. Cooney, Jesse Rissman, Mark D'Esposito. Nature Neuroscience, 2005

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How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Cognitive Neuroscience of Aging (2008, background): “Other studies have shown failures to suppress brain activity that were attributed to failure to inhibit irrelevant information (Gazzaley et al. 2005; Milham et al. 2002).”
Disruption of large-scale brain systems in advanced aging. (2007, background): “, 2001; Sullivan and Pfefferbaum, 2006) and nonspecific functional activity patterns (Park et al., 2004; Gazzaley et al., 2005; Cabeza, 2002).”
Que PASA? The posterior-anterior shift in aging. (2008, result): “These ﬁndings are consistent with several studies that show age-related dedifferentiation in sensory processing (Park et al. 2004; Gazzaley et al. 2005).”
A taxonomy of external and internal attention. (2011, positive): “Working memory maintenance directly modulates processing in relevant sensory cortex (Harrison & Tong 2009, Serences et al. 2009), and suppresses irrelevant information (Gazzaley et al. 2005).”
Intelligence and neural efficiency. (2009, positive): “This hypothesis suggests that impairments in cognitive performance are the result of the inability to suppress cortical activity associated with taskirrelevant information (for recent evidence in this field see Gazzaley et al., 2005, 2008).”