Coupling mRNA processing with transcription in time and space
By D. Bentley. Nature reviews genetics, 2014
763 citations recorded by the source corpus.
Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the evolution of coupling mechanisms that coordinate transcription with mRNA capping, splicing, editing and 3′ end formation. Recent experiments using sophisticated new methods for analysis of nascent RNA have provided important insights into the relative amount of co-transcriptional and post-transcriptional processing, the relationship between mRNA elongation and processing, and the role of the Pol II carboxy-terminal domain (CTD) in regulating these processes.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/cb371b5c1241259c1cee57302d5713ed1974a802
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Citations in the corpus
- mRNA-based therapeutics: powerful and versatile tools to combat diseases (2022, background): “Intriguingly, GTP first binds to RNA chains via a 5′-5′ triphosphate bond and then 7-methylation of the 5′ terminal guanosine in posttranscriptional capping.(115) Capping enzymes from vaccinia virus are widely used to cap mRNA, have high end-capping efficiency and are able to completely cap mRNA wit”
- circRNA biogenesis competes with pre-mRNA splicing. (2014, background): “, capping and splicing factors [Bentley, 2014]).”
- The nuts and bolts of the endogenous spliceosome (2017, result): “It is however consistent with the cotranscriptional splicing model and especially with the model of cotranscriptional commitment to splicing.(50,58) The supraspliceosome model is consistent with most imaging studies, and different interpretations can account for the limited discrepancies.”