Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

By A. Hartmann, S. Hunot, P. Michel, M. Muriel, S. Vyas, B. Faucheux, A. Mouatt‐Prigent, H. Turmel, A. Srinivasan, M. Ruberg and 3 more. Proceedings of the National Academy of Sciences of the United States of America, 2000

720 citations recorded by the source corpus.

Subfields: Law

View Paper: https://www.semanticscholar.org/paper/caf1c8858f247c79476135ff209ffa80bfde46d7

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1. S. Przedborski
2. W. Dauer
3. R. Betarbet
4. S. Ghavami
5. A. Panov
6. S. Shojaei
7. T. Sherer
8. A. Stout

Citations in the corpus

• An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage (2002, background): “Brains from PD patients show evidence of apoptosis, including fragmented nuclei and caspase activation (Tatton et al., 1998; Hartmann et al., 2000; Tatton, 2000).”
• Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, positive): “Factors that cause disruption of lysosomal membranes are likely to induce necrosis during which released lysosomal hydrolases participate as both a trigger and as executioners along with caspases that are activated by cathepsin-mediated cleavage (Hartmann et al., 2000; Werneburg et al., 2004).”
• Parkinson's Disease Mechanisms and Models (2003, background): “…of DA produces effector protease caspase-3 have also been found inhydrogen peroxide and superoxide radicals, and autogreater proportion in PD (Hartmann et al., 2000, 2002).oxidation of DA produces DA-quinone (Graham, 1978), Other molecular markers of PCD are altered in PD, in-a molecule that…”