Generation of Tumor-Infiltrating Lymphocyte Cultures for Use in Adoptive Transfer Therapy for Melanoma Patients

By M. Dudley, J. Wunderlich, Thomas E. Shelton, J. Even, S. Rosenberg. Journal of immunotherapy, 2003

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Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy (2005, background): “Despite efficient approaches for rapid expansion of tumor-specific T cells in vitro [20, 38, 40, 49], the data regarding long-term survival of tumor-specific T cells after transfer into patients are controversial.”
Generation of tumor-reactive T cells by co-culture of peripheral blood lymphocytes and tumor organoids (2018, unknown): “Tumor Organoids Are Killed by Autologous Tumor-Reactive T Cells T cells were obtained by 2-week co-culture with autologous tumor organoids and, where indicated (by a lowercase ‘‘e’’), further expanded using a rapid expansion protocol (Dudley et al., 2003), in some cases preceded by CD137-based enric”
Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens (2008, methodology): “TIL Cultures and Immunologic Monitoring Assays TIL cultures for patient treatment were generated as previously described.(3,13) The phenotype of TIL was determined by fluorescence-activated cell sorting (FACS) analysis and the antigen specificity was assessed by cytokine-release assays using standar”