Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors

By Valerie B. Caraiscos, Erin M. Elliott, K. E. You-Ten, V. Cheng, D. Belelli, J. Newell, M. F. Jackson, J. Lambert, T. Rosahl, K. Wafford and 2 more. 2004

551 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cad3314971e4e6392fe691f59eee498880372f36

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Citations in the corpus

Extrasynaptic GABAA receptors: Their function in the CNS and implications for disease (2012, background): “…GABAARs (a5-GABAARs) generate a tonic conductance that regulates the excitability of pyramidal neurons in CA1 and CA3 regions of the hippocampus (Caraiscos et al., 2004; Glykys andMody, 2006, 2007; Pavlov et al., 2009; Prenosil et al., 2006; Semyanov et al., 2004) and layer 5 cortical neurons…”
Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference (2015, background): “…and increased c-Fos expression As expected based on previous studies showing the role of 5- GABAARs in tonic inhibition in other hippocampal areas (Caraiscos et al., 2004), 5DGKO mice had reduced amplitude of tonic currents in DGCs compared with F/F control mice (unpaired t test, t(12) 2.79, p…”
GABAA Receptors: Subtypes Provide Diversity of Function and Pharmacology (2008, unknown): “…appear to reflect those of a native subtype found in CA1 pyramidal neurons (that are enriched in both a5 and b3 subunits) and are distinct from receptors in dentate gyrus granule cells (Burgard et al., 1996; Sur et al., 1998; McClellan and Twyman, 1999; Stell et al., 2003; Caraiscos et al., 2004).”
International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update (2008, background): “…to reflect those of a native subtype found in CA1 pyramidal neurons, cells enriched in both (cid:2) 5 and (cid:7) 3 subunits, and distinct from receptors in dentate gyrus granule cells (Burgard et al., 1996; Sur et al., 1998; McClennan and Twyman, 1999; Stell et al., 2003; Caraiscos et al., 2004).”
Hippocampal α5 subunit-containing GABAA receptors modulate the expression of prepulse inhibition (2005, background): “23 Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, Lee E et al. (1996) Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci USA 93: 5860–5865. 24 Zhang WN, Bast T, Feldon J (2002) Effects of hippocampal N-”
Synaptic and nonsynaptic localization of GABAA receptors containing the α5 subunit in the rat brain (2006, background): “Moreover, the 5 / mouse mutant has reduced tonic currents, while they show no change in the mIPSCs when compared with the control nonmutant mouse (Caraiscos et al., 2004).”
Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning (2015, background): “Etomidate is a positive allosteric modulator at GABAA receptor (Evans and Hill, 1978) and a5 subunit-containing GABAA receptors are highly sensitive to etomidate, producing a strong increase in tonic but not phasic inhibition (Caraiscos et al., 2004).”