Default-mode and task-positive network activity in Major Depressive Disorder: Implications for adaptive and maladaptive rumination

By J. P. Hamilton, Daniella J. Furman, Catie Chang, Moriah E. Thomason, Emily L. Dennis, Ian H. Gotlib. Biological Psychiatry, 2011

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Background Major Depressive Disorder (MDD) has been associated reliably with ruminative responding; this kind of responding is composed of both maladaptive and adaptive components. Levels of activity in the default-mode network (DMN) relative to the task-positive network (TPN), as well as activity in structures that influence DMN and TPN functioning, may represent important neural substrates of maladaptive and adaptive rumination in MDD. Methods We used a unique metric to estimate DMN dominance over TPN from blood-oxygen-level dependent data collected during eyes-closed rest in 17 currently depressed and 17 never-disordered adults. We calculated correlations between this metric of DMN dominance over TPN and the depressive, brooding, and reflective subscales of the Ruminative Responses Scale, correcting for associations between these measures both with one another and with severity of depression. Finally, we estimated and compared across groups right fronto-insular cortex (RFIC) response during initiations of ascent in DMN and in TPN activity. Results In the MDD participants, increasing levels of DMN dominance were associated with higher levels of maladaptive, depressive rumination and lower levels of adaptive, reflective rumination. Moreover, our RFIC state-change analysis showed increased RFIC activation in the MDD participants at the onset of increases in TPN activity; conversely, healthy control participants exhibited increased RFIC response at the onset of increases in DMN activity. Conclusions These findings support a formulation in which the DMN undergirds representation of negative, self-referential information in depression, and the RFIC, when prompted by increased levels of DMN activity, initiates an adaptive engagement of the TPN.

Subfields: Cognitive Neuroscience, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/caa256d30fcfbab35caa80c7f61faa28fb2879be

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Citations in the corpus

Conn: A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks (2012, neutral): “…et al., 2009; Whitﬁeld-Gabrieli and Ford 2012), ADHD (Castellanos et al., 2008), autism (Weng et al., 2010), depression (Greicius et al., 2007; Hamilton et al., 2011), bipolar disorder (Chai et al., 2012), and Alzheimer’s disease (Buckner et al., 2009; Greicius et al., 2004; Wang et…”
Resting state functional connectivity in addiction: Lessons learned and a road ahead (2012, methodology): “Supporting such a proposal, self-reported improved concentration following nicotine administration to abstinent smokers has been associated with increased negative coupling between DMN and TPN regions (Fig.”
Depressive Rumination, the Default-Mode Network, and the Dark Matter of Clinical Neuroscience (2015, background): “Although ruminative responding is not considered a criterion symptom of depression in DSM-5 or ICD-10, measures of rumination nonetheless consistently (and often, perfectly, e.g., 6) differentiate depressed from never-depressed individuals.”
EEG correlates of time-varying BOLD functional connectivity (2013, neutral): “…include the dACC, anterior insula, and thalamus, has been proposed to influence the activity in theDMNandDAN in both task conditions and resting state (Hamilton et al., 2011; Menon and Uddin, 2010) acting as a “switch” between the respective endogenous and exogenous functions of these networks.”
Tracking whole-brain connectivity dynamics in the resting state. (2014, neutral): “…on D ecem ber 11, 2012 http://cercor.oxfordjournals.org/ D ow nloaded from between behavior and connectivity patterns (e.g., Kelly et al. 2008; Hamilton et al. 2011; Thompson et al. 2012), it will become more important to understand the relevant time scales over which FC (and FC changes)…”
Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression (2020, neutral): “, 2016; Joormann and Quinn, 2014) and neural (Hamilton et al., 2011; Vanderhasselt et al., 2011) mechanisms of trait rumination.”