Inflammation is detrimental for neurogenesis in adult brain

By Christine T. Ekdahl, J. Claasen, S. Bonde, Z. Kokaia, O. Lindvall. Proceedings of the National Academy of Sciences of the United States of America, 2003

1,607 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/ca89fb35ef6139ddc4410e6ee2dcaf38d9879471

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Citations in the corpus

Neuroinflammation and depression: A review (2020, background): “Microglial cells seem to be key players, as LPS-induced microglial activation inhibits hippocampal neurogenesis (Ekdahl et al., 2003; Monje et al., 2003).”
The potential of neural stem cells to repair stroke-induced brain damage (2009, background): “However, minocycline did not inXuence neurogenesis in normal animals that show very few activated microglia in the hippocampus [ 23 ].”
Electroconvulsive seizure restores neurogenesis and hippocampus‐dependent fear memory after disruption by irradiation (2008, background): “Inflammation, characterized by an increase in activated microglia, is one factor involved in the suppression of neurogenesis by IRR (Ekdahl et al., 2003; Mizumatsu et al., 2003; Monje et al., 2003; Rola et al., 2004).”
Microglia in the TBI Brain: The Good, The Bad, And The Dysregulated (2015, background): “…which drives a pronounced M1-like activation profile in microglia, strongly impairs basal hippocampal neurogenesis levels in adult rats (Ekdahl et al., 2003; Monje et al., 2003); an effect that can be restored when anti-inflammatory drugs, such as indomethacin or minocycline, are…”
Experimental autoimmune encephalomyelitis repressed by microglial paralysis (2005, background): “Recent reports suggest an inverse relationship between microglial activation and neurogenesi”
Persistent Production of Neurons from Adult Brain Stem Cells During Recovery after Stroke (2006, background): “It is conceivable that inflammatory changes accompanying the ischemic damage [27] contribute to the poor survival of the new striatal neurons [ 28 , 29].”
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later (2015, background): “In the adult SGZ, one population-level study suggested that NSC activation leads to multiple rounds of proliferation, which is coupled with their depletion via differentiation into astrocytes without their ever returning to quiescence (Encinas et al., 2011).”
Reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice (2007, positive): “It has been proposed that microglial activation is a causal factor for a persisting reduction of AhN (Monje and Palmer, 2003), and that a blockade of the inflammatory reaction after irradiation partially restores AhN (Ekdahl et al., 2003; Monje et al., 2003).”
Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia (2008, background): “Minocycline is a tetracycline-type antibiotic that has antiinflammatory properties in the CNS [41-43,45].”
Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017, background): “Inflammatory processes may have a critical role in the etiology of hippocampal atrophy, as translational work in rodent models indicates that cytokines released from microglia inhibit neurogenesis within the dentate gyrus (Ekdahl et al, 2003) and promote neuronal apoptosis (Cunningham et al, 2005).”
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016, neutral): “Inflammation is known to sharply inhibit neurogenesis in the adult brain (Ekdahl et al., 2003) through the microglial release of inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a).”
Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers (2017, background): “, 2015) and previously shown to modulate neurogenesis in in vivo rodent models (Ekdahl et al., 2003; Monje et al., 2003).”
Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke. (2016, background): “However, they also impair brain recovery by initiating the inflammatory cascade and releasing a considerable amount of inflammatory cytokines that hinder neuronal repair (Ekdahl et al., 2003; Miron et al., 2013; Zhou et al., 2014).”
Adult neurogenesis: from precursors to network and physiology. (2005, background): “355, 466, 565), 2) chronic stress increases its production in aged patients (272), 3) IL-6 expression is increased in the HF of senescence-accelerated mice (539), and 4) hippocampal neurogenesis is reduced in adult transgenic mice with chronic IL-6 production (552) or after administration of bacteri”
Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system (2005, background): “They also may inhibit neurogenesis in the adult brain (36).”