Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

By R. Paolicelli, G. Bolasco, F. Pagani, L. Maggi, Maria Scianni, P. Panzanelli, M. Giustetto, Tiago A. Ferreira, Eva Guiducci, L. Dumas and 2 more. Science, 2011

3,916 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/ca7f905a4115266720cf5a5e5d0b6c772b82f3a5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Pekny
2. M. Sofroniew
3. M. Pekna
4. E. Hol
5. Alexei Verkhratsky
6. Beth Stevens
7. M. Colonna
8. O. Butovsky

In Immunology

1. R. Ransohoff
2. Steffen Jung
3. A. Mildner
4. Florent Ginhoux
5. B. Barres
6. C. Varol
7. Beth Stevens
8. Miriam Merad

In Neurology

1. R. Ransohoff
2. M. Sofroniew
3. M. Pekny
4. B. Barres
5. M. Pekna
6. Beth Stevens
7. Alexei Verkhratsky
8. E. Hol

Citations in the corpus

• Microglia promote learning-dependent synapse formation through BDNF (2013, background): “…suggested that microglia are involved in synaptic pruning through the phagocytosis of synapses during early postnatal periods, and that this process can be disrupted by loss of the fractalkine receptor CX3CR1 (Paolicelli et al., 2011) or complement receptor 3 (CR3/CD11b) (Schafer et al., 2012).”
• Origin and differentiation of microglia (2013, background): “Microglia also contribute to the remodeling of post-natal neural circuits as they have been recently shown to play a role in synaptic pruning during post-natal development in mice (Paolicelli et al., 2011).”
• Astrocytes: a central element in neurological diseases (2016, background): “1 3 due to the lack of CX3CR1 chemokine receptor [167].”
• Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner (2012, positive): “Furthermore, microglia can contribute to synaptic plasticity in the adult CNS and, more recently, in the context of the normal developing hippocampus (Paolicelli et al., 2011; Pascual et al., 2012; Roumier et al., 2008).”
• Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways (2013, neutral): “6d), likely due to a higher rate of developmental synapse pruning of excitatory projections in the younger brains 30 .”
• Depression as a microglial disease. (2015, background): “In the developing CNS, microglia regulate the neuronal precursor cell pools as well as synaptogenesis and neural network formation [174,175].”