Mechanisms of thrombus formation.

By B. Furie, B. Furie. New England Journal of Medicine, 2008

1,832 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Genetics, Hematology

View Paper: https://www.semanticscholar.org/paper/ca6c90242f6d61719579686c68f9e7f3516e5016

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Jean-Louis Vincent
2. Aldons J. Lusis
3. S. Jackson

In Genetics

1. Aldons J. Lusis
2. S. Jackson
3. Donat R. Spahn

In Hematology

1. S. Jackson
2. Donat R. Spahn

Citations in the corpus

• Arterial thrombosis—insidious, unpredictable and deadly (2011, background): “Thrombosis is primarily mediated by platelets and fibri”
• Management of bleeding and coagulopathy following major trauma: an updated European guideline (2013, background): “(Grade 2C) Rationale Fibrinogen is the final component in the coagulation cascade, the ligand for platelet aggregation and, therefore, key to effective coagulation and platelet function [233,369].”
• Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “…trigger thrombus formation in vivo (Biró et al., 2003), are abundantly present in human atherosclerotic plaques (Mallat et al., 1999), and may be deposited at a site of vascular injury by binding to activated platelets (Furie and Furie, 2004; Del Conde et al., 2005; Furie and Furie, 2008).”
• The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition (2016, background): “Fibrinogen is the final component in the coagulation cascade, the ligand for platelet aggregation and therefore key to effective coagulation and platelet function [280, 420].”
• Wound Healing: A Cellular Perspective. (2019, background): “Next, primary hemostasis and secondary hemostasis occur via two concurrent and mechanistically intertwined pathways (129).”
• Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk (2016, positive): “However, at sites of vessel injury, platelets are rapidly activated by stimulus-dependent mobilization of [Ca2+]i, a precursor to thrombus formation and hemostasis (Rink and Sage, 1990; Furie and Furie, 2008).”
• Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo (2009, positive): “Platelets play a pivotal role in vascular occlusive disease (Furie and Furie, 2008; Ruggeri, 2002).”
• Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety (2019, background): “A thrombus is a solid mass of platelets, red blood cells, and fibrin mesh that typically forms as a response to vessel wall injury and is part of the normal healing cascade (Furie and Furie, 2008).”
• The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition (2019, background): “Fibrinogen is the final component in the coagulation cascade, the ligand for platelet aggregation and therefore key to effective coagulation and platelet function [377, 639].”
• Management of bleeding following major trauma: an updated European guideline (2010, background): “Rationale The formation of fibrin is a key step in blood coagulation [222,279], and hypofibrinogenemia is a usual component of complex coagulopathies associated with massive bleeding.”