CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-101

By O. Annacker, Ricardo Pimenta‐Araujo, O. Burlen-Defranoux, Theolis Barbosa, A. Cumano, A. Bandeira. Journal of Immunology, 2001

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Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide (2003, background): “CD4 CD45RBlow CD25 cells exert regulatory functions in vivo (31), but do not show suppressor activity in vitro when freshly isolated (Fig.”
Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function (2002, background): “Third, whereas the control of in vitro proliferation by CD25 T cells appears to be cytokine independent, in vivo protection from IBD by CD25 T cells has been shown to be cytokine dependent (24, 25).”
Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells (2004, background): “The capacity of Tregs to suppress activation and proliferation of naive T cells (12) suggests that they act in a lymphoid environment.”
Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells1 (2003, result): “The finding that CD4 CD25 TR cells expand in the spleen and the MLN after transfer into immunodeficient mice is consistent with a previous report (14).”
CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses1 (2002, background): “In contrast, two recent studies have shown that peripheral CD4 CD25 T cells contain regulatory cells that prevent autoimmune disease (36, 37).”