Early infancy microbial and metabolic alterations affect risk of childhood asthma
By M. Arrieta, Leah T. Stiemsma, P. Dimitriu, L. Thorson, Shannon L. Russell, Sophie Yurist-Doutsch, B. Kuzeljevic, Matthew J. Gold, Heidi M. Britton, D. Lefebvre and 10 more. Science Translational Medicine, 2015
1,555 citations recorded by the source corpus.
Subfields: Emergency Medical Services, General Health Professions, Physiology
View Paper: https://www.semanticscholar.org/paper/ca2afb1b41edf7e4686fdec3bb697efa2cb2d535
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In General Health Professions
In Physiology
Citations in the corpus
- The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “The concept that microbial products associated with a disease-susceptible microbiome drive heritable immune dysfunction was supported by a study showing that fecal microbiota transfer from infants at high risk for asthma into GF mice resulted in exacerbated allergic lung inflammation in their adult ”
- A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome (2017, background): “Research in both animal models and humans suggests that the process of microbial colonization is especially significant during early life, as this period constitutes a critical window for immunological and physiological development [2, 3].”
- Impact of antibiotics on the human microbiome and consequences for host health (2022, background): “Due to the role of the microbiota in host metabolism and physiology, many studies postulate that microbial imbalances can be related to obesity (Riley et al., 2013; Scott et al., 2016), diabetes (Boursi et al., 2015; Mikkelsen et al., 2015), and asthma (Arrieta et al., 2015; Kozyrskyj et al., 2007).”
- Antibiotic use and its consequences for the normal microbiome (2016, background): “Observational, clinical, and epidemiologic studies focused on young children are providing a growing body of evidence that antibiotic exposure is associated with increased risk for a variety of diseases including obesity, types 1 and 2 diabetes, inflammatory bowel diseases, celiac disease, allergies”
- Neonatal gut microbiota associates with childhood multi–sensitized atopy and T–cell differentiation (2016, neutral): “3-methylglutarylcarnitine (1) Caprylate (8:0) 13-HODE + 9-HODE 12,13-DiHOME 9,10-DiHOME r = 0.”
- Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health (2016, background): “For instance, butyrate producers are normally low in ulcerative colitis (Machiels et al., 2014) and reduced levels of propionate producers have been detected in children at risk of asthma (Arrieta et al., 2015).”
- The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks (2020, background): “Inoculation of the bacteria absent in the microbiota of asthmatic patients decreases airways inflammation (Arrieta et al., 2015).”
- Microbiota in health and diseases (2022, background): “discovered that the abundance of Veillonella, Faecalibacterium, and Lachnospira were significantly decreased in children at risk of asthma.(206) It is suggested that the gut bacterial metabolites may contribute to asthma through its immune modulation.”